Features of the functioning of B-2 lymphocytes in patients with common variable immune deficiency in post-vaccination immunity to SARS-CoV-2

Objective: B-2 lymphocytes characteristic of patients with CVID in the process forming a post-vaccination response to peptide vaccine against SARS-CoV-2. Materials and methods: 10 people diagnosis were included study among cohort primary immunodeficiency under supervision Research Institute Department Clinical Immunology allergology Rostov State Medical University. For immunoprophylaxis COVID-19, recombinant was used, which administered intramuscularly at dose 0.5 ml twice an interval 21 days. The parameters immune system evaluated before vaccination, then days after first second doses 72 injection. Phenotypic peripheral blood B cells performed by cytofluoriometry flow method. Results: number memory phenotypic option switched unswitched antibody synthesis lower than control practically healthy donors. administration dose, increase un-switched cells, plasma blasts, decrease proportion B-regulatory noted relation initial values. injection, total pool lymphocytes, naive blasts revealed. A month later, this tendency continued. Conclusion: SARS-CoV-2 CVID, transformation subpopulation composition revealed, as well form B2 lymphocytes.